What Causes High Uric Acid? Understanding the Root Factors

TL;DR: High uric acid is caused by overproduction (high-purine foods, alcohol, fructose, medications) or under-excretion (kidney issues, dehydration, genetics). Understanding your personal triggers helps you take targeted action.

The Two Main Causes

Your body either makes too much uric acid or cannot eliminate it efficiently. Diet, lifestyle, and genetics all play roles.

Diet Triggers

High-purine foods like red meat, organ meats, shellfish, and alcohol (especially beer) significantly raise uric acid. Fructose-rich drinks also increase production.

Kidney Function

Your kidneys filter 70% of uric acid. Chronic kidney disease, dehydration, or genetic variants affecting kidney function can lead to accumulation.

Medications

Diuretics, low-dose aspirin, and certain immunosuppressants can elevate uric acid levels.

Metabolic Factors

Obesity, insulin resistance, and metabolic syndrome are strongly linked to high uric acid. Weight loss often improves levels significantly.

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